Saturday September 24th 2016


Royal College of Physicians, Kildare Street, Dublin 2


17.30 - 19.30             Registration

19.30 - 21.30             Welcome Reception


Sunday September 25th 2016


Dublin Castle Conference Centre, Dame Street, Dublin 2


07.30 - 08.30             Registration

08.30 - 08.45             Welcome: Prof Donnelly and Prof Keane


Plenary Scientific Session 1

Chair: Prof Donnelly and Prof Laurent


08.45 - 09.15             Hal Collard, UCSF, USA

                                    ‘Possible IPF: How we got in this mess and how we got out'

09.15 - 09.30             Rosemary Kane, University College Dublin, Ireland

‘Serum exosomes from IPF patients contain miR-125b, which is           correlated to severity of disease progression'

09.30 - 09.45             Pierre-Simon Bellaye, McMaster University, Canada

‘Pathogenesis of Pulmonary Fibrosis - The Role of Extracellular Heat Shock Protein-90 (HSP90) in Myofibroblast Differentiation and Persistence'

09.45- 10.00              Chiko Shimbori McMaster University, Canada

‘Mechanical stress-induced mast cell degranulation activates TGFβ-1 signalling pathway in pulmonary fibrosis'

10.00 - 10.15             Lisa Nicol, University of Edinburgh, Scotland

‘Identification of alveolar macrophage phenotypes predictive of disease progression in idiopathic pulmonary fibrosis'

10.15 - 10.30             Rachel Knipe, Harvard Medical School, Boston, USAROCK Isoforms ROCK 1 and ROCK 2 are Critical for the Development of Pulmonary Fibrosis in Several Different Cell Specific Mechanisms


10.30 - 11.15 Coffee Break


Plenary Scientific Session 2

Chair: Prof White and Prof Kolb


11.15 - 11.30             Amiq Gazdhar, University Hospital, Bern, Switzerland

‘New Alveolar epithelial cell line to study lung injury and fibrosis'

11.30 - 11.45             Brintha Selvarajah, University College London UK

‘Metabolic shift during TGF-β induced collagen synthesis'

11.45 - 12.00             Ilan Azuelos, University College London, UK

‘mTOR regulates glucose metabolism during TGFβ-Induced fibroblast to myofibroblast differentiation'

12.00 - 12.15             Louise Organ, University of Melbourne, Australia

‘KCa3.1 channel-blockade reduces both human and ovine pulmonary fibroblast proliferation in vitro'


12.15 - 14.00             Lunch & Poster Viewing (from 13.00hrs)

Poster Chairs: Prof Raghu, Prof Collard, Prof Cox, Prof Doran



Plenary Scientific Session 3

Chair: Prof Richeldi & Prof Raghu


14.00 - 14.30             Luke O'Neill, Trinity College Dublin, Ireland

                                    ‘New Frontiers in Inflammatory Research'

14.30 - 14.45             David McAllister, University of Edinburgh, Scotland

‘The natural history of asbestosis and idiopathic pulmonary fibrosis according to HRCT phenotype'

14.45 - 15.00             Jonathan McQualter, University of Newcastle, Australia

‘Heterogeneity of lung mesenchymal lineages and its impact on tissue regeneration.'

15.00 - 15.15             Jiangning Tan, University of Pittsburgh, Pennsylvania, USA

‘Expression of RXFP1 is Decreased in Idiopathic Pulmonary Fibrosis: Implications for Relaxin-Based Therapies'

15.15 - 15.30             Brett Ley, University of California, San Francisco, USA

‘Reduction in Non-Elective Respiratory-Related Hospitalizations in Patients Treated With Pirfenidone: Pooled Analyses From Three Phase 3 Trials of Pirfenidone in Idiopathic Pulmonary Fibrosis'


15.30 - 1600             Coffee Break


Plenary Scientific Session 4

Chair Prof Sime & Prof Maher


16.00 - 16.30             David Schwartz, University of Colorado, USA

‘IPF: a genetic disease that involves mucociliary dysfunction in the peripheral airways'

16.30 - 16.45             Michelle Armstrong, Trinity College Dublin, Ireland

‘Toll-like receptor 3 (TLR3) L412F single nucleotide polymorphism promotes disease progression in idiopathic pulmonary fibrosis (IPF): implications for viral and bacterial infection in TLR3-defective patients.'

16.45 - 17.00             Antje Prasse, Medical School Hannover, Germany

Airway basal cells of patients with IPF are epigenetically reprogrammed and promote fibrosis

17.00 - 17.15             Gunnar Gudmundsson, University of Iceland

MUC5B and Radiologic Subtypes of Interstitial Lung Abnormalities in the AGES-Reykjavik Study

17.15 - 17.30             Fernando Martinez, Weill Cornell Medical College, USA

Diagnosis of Idiopathic Pulmonary Fibrosis: Accurate Molecular Detection of Usual Interstitial Pneumonia Pattern in Transbronchial Biopsies using RNA Sequencing



17.30                          Dublin Castle Tour



Monday September 26th 2016


Dublin Castle Conference Centre, Dame Street, Dublin 2


Plenary Scientific Session 5

Chair: Prof Doran & Prof Cox


08.00 - 08.30             Cory Hogaboam, Cedar Mount Sinai, USA

                                    ‘Innate immune mechanisms regulating progression to IPF'

08.30 - 08.45             Guoying Yu, Yale University, USA

‘Thyroid hormone inhibits pulmonary fibrosis through enhancement of mitochondrial function in alveolar epithelial cells'

08.45 - 09.00             David Habiel, Cedars-Sinai Medical Center, Los Angeles, USA

‘Characterization of Profibrotic EphA3 Expressing Cells in IPF Lungs'

09.00 - 09.15             Jingang Huang, University of Erlangen-Nuermberg, Germany

‘Nintedanib ameliorates pulmonary and dermal fibrosis in preclinical models of systemic sclerosis'

09.15 - 09.30             Lurdes Planas, University Hospital of Bellvitge, Barcelona, Spain

‘Biological age instead of chronologic age as prognostic factor in IPF: clinical implications of telomere shortening'

09.30 - 09.45             Nick Lukacs, University of Michigan, USA

                                    ‘Stell cell factor (kitig) in airway and lung remodeling'


09.45 - 11.00             Coffee Break & Poster viewing

                                    Poster Chairs: Prof Sime, Prof Richeldi, Prof Wijsenbeek, Prof Hirani



Plenary Scientific Session 6

Chair: Prof Donnelly & Prof Fabre


11.00 - 11.30             Varda Rotter, Weizmann Institute, Israel

                                    ‘The cancer associated fibroblast'

11.30 - 11.45             Ting Xie, Cedars-Sinai Medical Center, California, USA

‘Regulation of myofibroblast accumulation and lung fibrosis by Tbx4'

11.45 - 12.00             Jeffrey Horowitz, University of Michigan, USA

                                    ‘X-linked Inhibitor of Apoptosis (XIAP) Regulates Suppression of Fibroblast Autophagy by TGF-beta1 and Rigid Extracellular Matrix Substrates'

12.00 - 12.15             Gerald Burgstaller, Helmholtz Centre Munich, Germany

‘A dual role of SFRP1 in lung fibrosis' (152)

12.30 - 12.45             Antoine Froidure, Paris Diderot University, France

‘Transcription factor PRRX1 is a master-regulator of IPF fibroblasts'


13.00                          Packed Lunch

Free Afternoon and pre-arranged activities


19.30                          Conference Irish Night

                                    Commons Room, Front Square, Trinity College Dublin



Tuesday September 27th 2016


Dublin Castle Conference Centre, Dame Street, Dublin 2


08.00 - 08.30             Registration


Plenary Scientific Session 7

Chair: Prof Keane & Prof Collard


08.30 - 09.00             John Belpiero, UCLA, USA

                                    ‘Fibrosis & Lung Transplantation

09.00 - 09.15             Robert Brownell, University of California, SF USA

Prediction of histopathologic usual interstitial pneumonia among ILD cases with a non-diagnostic high-resolution computed tomography scan

09.15 - 09.30             Steven Gurczynski, University of Michigan, USA

‘Notch signaling regulates herpesviral-induced pneumonitis and fibrosis post-stem cell transplant'

09.30 - 09.45             Joseph Jacob, Royal Brompton Hospital, UK

Rheumatoid arthritis related interstitial lung disease: identification of patients with an idiopathic pulmonary fibrosis equivalent outcome using automated CT analysis

09.45 - 10.00             Gavin Tjin, Australian Centre for Microscopy and Microanalysis

‘TGF-β Induced Collagen Remodelling by IPF Fibroblasts is Alleviated by Inhibition of Lysyl Oxidase Enzyme Activity'

10.00 - 10.30             Rachel Chambers, University College London, UK

                                    ‘The role of the PI3K/AKT/mTOR axis in regulating fibroblast function'


10.30 - 11.00             Coffee Break


Plenary Scientific Session 8

Chair Prof Hirani & Prof Jenkins


11.00 - 11.30             Kevin Brown, University of Colorado, USA

                                    ‘Lessons Learned in Clinical Trials in Pulmonary Fibrosis'

11.30 - 11.45             David Lagares, Harvard Medical School, Boston, USA

‘Targeting fibroblast durotaxis as novel anti-fibrotic therapy for IPF'

11.45 - 12.00             Margaret Neighbors, Genentech, San Francisco, USA

‘Assessment of Prognostic and Predictive Properties of Blood Biomarkers in Pivotal Clinical Studies of Pirfenidone'

12.00 - 12.15             Nik Hirani, University of Edinburgh, Scotland

‘TD139, A Novel Inhaled Galectin-3 Inhibitor for The Treatment of Idiopathic Pulmonary Fibrosis (IPF). Results from The First in (IPF) Patients Study'

12.15 - 12.45             Michael Zeisberg, Georg-August-Universität Göttingen, Germany

                                    Update on Mechanisms of Renal Fibrosis


12.45 - 14.00             Lunch & Poster Viewing from 13.00

Poster Chairs: Prof Jenkins, Prof Maher, Prof Johannson, Prof Fabre

P068 - P101


Plenary Scientific Session 9

Chairs: Prof David Lynch & Prof Athol Wells


14.00 - 14.15             David Lynch, University of Colorado, USA

                                    ‘Quantitative CT of pulmonary fibrosis'

14.15 - 14.30             John Dodd, University College Dublin, Ireland

                                    ‘Delayed contrast MRI'

14.30 - 14.45             Bastiaan Driehuys, Duke University, USA

                                    ‘Hyperpolarised Xenon'

14.45 - 15.00             Ashley Groves, University of London, UK

                                    ‘PET - CT'

15.15 - 15.30             GraceHyun Kim, UCLA, USA

‘Prediction of IPF with the Early Changes in Quantitative Imaging Patterns Using High Resolution Computed Tomography'

15.30 - 15.45             Darryl Knight, University of Newcastle, UK

‘Using Maldi-imaging to investigate region-specific proteome in IPF Lung'


15.45 - 16.30             Coffee Break


16.30 - 17.30             Ask the Experts on Clinical Conundrums

                                    Moderator: Katherine O'Reilly, University College Dublin

                                    Clinical Experts: Prof Raghu, Prof Wells, Prof King


19.30                          Conference Dinner

                                    Round Room, Mansion House, Dawson Street, Dublin 2


Wednesday September 28th 2016


Dublin Castle Conference Centre, Dame Street, Dublin 2


Plenary Scientific Session 10

Chair Prof Laurent & Prof Kolb


08.30 - 09.00             John Iredale, University of Bristol, UK

                                    ‘What we can learn from Liver Fibrosis'

09.00 - 09.30             Chris Watson, Queens University, Belfast, UK

                                    ‘What we can learn from Cardiac Fibrosis'


09.30 - 11.00             Coffee Break & Poster Viewing

Poster Chairs: Prof Kolb, Prof Lynch, Prof Molina, Prof Danoff




Plenary Scientific Session 11

Chair: Prof Richeldi & Prof Maher


11.00 - 11.30             Paul Noble, Cedar Mount Sinai, USA

‘The role of the invasive fibroblast in severe pulmonary fibrosis.'

11.30 - 11.45             Carol Liang, Cedars-Sinai Medical Center, USA

‘Hyaluronan and TLR4 Interactions Regulate Surfactant Protein C-positive Alveolar Progenitor Cell Renewal and Prevent Severe Pulmonary Fibrosis'

11.45 - 12.00             Argyrios Tzouvelekis, Yale University, USA

‘H2 domain-containing phosphatase-SHP-2 is a novelregulator of fibroblast homeostasis in Pulmonary Fibrosis'

12.00 - 12.15             Kamran Atabai, University of California San Francisco, USA

‘Loss Of Fatty Acid Synthase Increases The Severity Of Lung Fibrosis By Preventing Collagen Resorption'

12.15 - 12.30             Eric White, University of Michigan, USA

‘A 5-Analyte Biomarker Panel is Associated With 48-Week Progression-Free Survival in IPF'


12.30                          Lunch and Departure

                                    UCD Choral Scholars perform ‘The Parting Glass'